Granulocyte transfusions in hematologic malignancy patients with invasive pulmonary aspergillosis: outcomes and complications

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Granulocyte transfusions in hematologic malignancy patients with invasive pulmonary aspergillosis: outcomes and complications.

BACKGROUND Granulocyte transfusions (GTXs) have been used successfully as an adjunctive treatment option for invasive infections in some neutropenic patients with underlying hematologic malignancy (HM). PATIENTS AND METHODS We sought to determine the impact of GTX as an adjunct to antifungal therapy in 128 patients with HM and prolonged neutropenia (≥14 days) with a proven or probable invasiv...

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Invasive pulmonary aspergillosis in patients with hematologic malignancies: survival and prognostic factors.

BACKGROUND AND OBJECTIVES Despite improvements made in its early diagnosis and effective treatment, invasive pulmonary aspergillosis (IPA) remains a devastating opportunistic infection. In this retrospective study we have reviewed all consecutive cases of IPA diagnosed in adult patients with hematologic malignancies in our center from 1995 to 2000 to determine survival and prognostic factors. ...

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Initial voriconazole trough blood levels and clinical outcomes of invasive aspergillosis in patients with hematologic malignancies.

There are limited data on the relationship between voriconazole levels and clinical outcomes relative to invasive aspergillosis (IA). We therefore analyzed the association between initial voriconazole trough blood levels and clinical responses of IA in patients with hematologic malignancies. All adult patients treated with voriconazole in a tertiary care hospital in Seoul, South Korea, between ...

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Pulmonary Hydatid Cyst Co-infected with Invasive Aspergillosis

Here we report a case of co-infection of hydatid cyst with invasive apergillosis, in a previously healthy, non immunocompromised, 26year old man. Chest x-ray revealed a large cystic cavity in left upper lobe of lung histopathologic examination of the specimen confirmed the diagnosis of hydatid cyst with numerous fungal hyphea which invaded the laminated wall of the cyst. Although, co-infection ...

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Prognosis of Invasive Pulmonary Aspergillosis in Patients with Hematologic Diseases in Korea

BACKGROUND The aim of this study was to investigate therapeutic outcomes and assess factors associated with therapeutic outcomes in hematologic patients with invasive pulmonary aspergillosis (IPA). METHODS We analyzed all consecutive cases of IPA in adults with hematologic diseases from January 2008 to January 2009 at a Catholic Hematopoietic Stem Cell Transplantation (HSCT) Center in Seoul, ...

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ژورنال

عنوان ژورنال: Annals of Oncology

سال: 2013

ISSN: 0923-7534

DOI: 10.1093/annonc/mdt110